Analysis of risk factors for hemorrhage in patients with acute poisoning treated with hemoperfusion.
10.3760/cma.j.cn121094-20210107-00006
- VernacularTitle:血液灌流治疗急性中毒患者并发出血的危险因素分析
- Author:
Ming Hao ZHANG
1
;
Ni WEI
1
;
Xiao Xi TIAN
1
;
Shun Zhong ZHAO
1
;
Li Hong LI
1
;
Bo Liang WANG
1
Author Information
1. Department of Emergency, the Second Affiliated Hospital of Air Force Military Medical University, Xi'an 710038, China.
- Publication Type:Journal Article
- Keywords:
Activated partial thromboplastin time;
Hemoperfusion;
Hemorrhage;
Poisoning;
Risk factors
- MeSH:
Hemoperfusion;
Hemorrhage/therapy*;
Humans;
Organophosphorus Compounds;
Pesticides;
Poisoning/therapy*;
Risk Factors
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(3):208-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the clinical characterist ics and risk factors of hemorrhage complicated by hemoperfusion therapy in patients with acute poisoning. Methods: In January 2021, the clinical data of 196 patients with acute poisoning who received hemoperfusion therapy in the Second Affiliated Hospital of Air Force Military Medical University from January 2018 to December 2020 were analyzed, and the patients were divided into bleeding group and non-bleeding group according to whether the patients were complicated with bleeding. Multivariate logistic regression was used to analyze the independent risk factors for hemorrhage in patients treated with hemoperfusion. Results: A total of 21 patients in the bleeding group and 175 patients in the non-bleeding group were included. There was no significant difference in general data such as gender, age, and body mass index between the two groups (P>0.05) . Organophosphorus pesticides (χ(2)= 4.56, P=0.030) , HA230 perfusion device (χ(2)=4.12, P=0.042) , platelet count (t=-2.33, P=0.009) and activated partial thromboplastin time (t=14.53, P<0.001) at 2 h of perfusion were the influencing factors of hemorrhage in patients with acute poisoning treated with hemoperfusion. Among them, organophosphorus pesticides, 2 h perfusion activated partial thromboplastin time ≥35 s and other factors were independent risk factors forcomplicated bleeding (P<0.05) . Conclusion: Patients with acute poisoning, especially organophosphorus pesticide poisoning, are at greater risk of bleeding during hemoperfusion therapy. Monitoring of changes in activated partial thromboplastin time should be strengthened and the dose of anticoagulants should be adjusted in time to reduce the risk of bleeding.
