Analysis of clinical effect of blood purification on acute benzene-based thinner poisoning.
10.3760/cma.j.cn121094-20201207-00670
- VernacularTitle:血液净化对急性苯系类稀料中毒治疗的临床效果分析
- Author:
Li Rong YANG
1
;
Xian CHEN
2
;
Ying Yu WEN
3
;
Ling Mei HA
2
;
Chao Bin YANG
2
Author Information
1. Medical Department of Military General, The Characteristic Medical Center of Armed Police, Tianjin 300162, China.
2. Department of Emergency, The Characteristic Medical Center of Armed Police, Tianjin 300162, China.
3. Department of Nephrology, The Characteristic Medical Center of Armed Police, Tianjin 300162, China.
- Publication Type:Journal Article
- Keywords:
Benzene;
Blood purification;
Poisoning;
Thinners;
Toxicological analysis
- MeSH:
Benzene;
Hazardous Substances;
Humans;
Poisoning/therapy*;
Prognosis;
Retrospective Studies
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(2):139-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical significance of blood purification on changes in serum toxicant concentration and prognosis of acute benzene-based thinner poisoning. Methods: A total of 44 patients with acute benzene-based thinner poisoning admitted to the emergency department of Characteristic Medical Center of Armed Police from August 2013 to August 2020 were collected and divided into a blood purification group (24 cases) and a conventional treatment group (20 cases) , the general data, toxicant concentrations and prognosis of the two groups of patients were analyzed, and logistic regression analysis was performed on the influencing factors of the prognosis to explore the clinical effect of blood purification. Results: The concentration of poisons in the blood purification group at 24 hours after treatment was significantly lower than that in the conventional treatment group (t=6.76, P<0.001) , and the reduction in the concentration of poisons was significantly higher than that in the conventional treatment group (t=3.33, P=0.002) . The overall improvement rate in the blood purification group was 91.7% (22/24) , which was higher than that in the conventional treatment group (60.0%, 12/20) . Logisitic regression analysis showed that blood purification treatment method was the main factor affecting the prognosis of patients (OR=7.605×10(-5), 95%CI: 6.604×10(-8)-0.087, P=0.008) , and the toxic dose was a synergistic effect on the prognosis of patients factor (OR=1.038, 95%CI: 1.008-1.068, P=0.011) . Conclusion: Early blood purification treatment in patients with acute benzene-based thinner poisoning can rapidly reduce blood toxin concentration, avoid disease progression, and ultimately improve patient prognosis.
