Case-control study of female breast cancer and occupational risk factors based on lasso logistic regression in Beijing.
10.3760/cma.j.cn121094-20201022-00592
- Author:
Ai Hua LI
1
;
Yan YE
1
;
Zhi Feng SUN
2
;
Xing Kuan TIAN
3
;
Gui Xin YU
1
;
Zhuang SHEN
1
Author Information
1. Beijing Center for Diseases Prevention and Control, Center of Preventive Medical Research, Beijing 100013, China.
2. Dongcheng Center for Diseases Prevention and Control, Beijing 100009, China.
3. Mentougou Center for Diseases Prevention and Control, Beijing 102300, China.
- Publication Type:Journal Article
- Keywords:
Beijing;
Breast cancer;
Case control;
Occupational risk factor
- MeSH:
Beijing;
Breast Neoplasms/epidemiology*;
Case-Control Studies;
Female;
Humans;
Logistic Models;
Risk Factors
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(2):109-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the relationship between female breast cancer and occupational risk factors in Beijing, and provide scientific basis for the formulation of prevention strategies and measures. Methods: From June to December 2019, A 1: 1 case-control study was adopted, eight medical institutions in Beijing were selected as the research objects. Patients with breast cancer diagnosed by medical institutions were selected as case group and non breast cancer patients in the same medical institution as control group. A total of 973 subjects were included, including 495 in the case group and 478 in the control group. A one-to-one survey was conducted using a questionnaire uniformly compiled by the Beijing Centers for Disease Control and Prevention. The survey content mainly includes basic demographic characteristics and occupational risk factors. The Trait Coping Style Questionnaire (TCSQ) was used to investigate the corresponding methods, including two aspects: positive coping and negative coping. First, chi square test or Wilcoxon rank sum test were used for univariate analysis. Then Lasso regression was used to screen the risk factors of breast cancer. Finally, the risk factors were screened by multivariate logistic regression analysis. Results: Education lovel was 49.64%, body mass index (BMI) was 18.4~23.9 kg/m(2), accounting for 48.82%, marital status ws 84.48%. Compared with no night shift history, there was a significant increase in risk of breast cancer at night shift history (OR=1.70, 95% CI: 1.25~2.30, P<0.05) . Compared with most of the sitting posture and sometimes standing, the risk of breast cancer was increased, and the difference was statistically significant (OR=2.01, 95%CI: 1.40~2.90, P<0.05) . Conclusion: In the occupation risk factors, night shift work and working posture are related to the incidence of breast cancer in women, establishing a good schedule and avoiding long standing can effectively prevent and reduce the occurrence of breast cancer.
