Analysis of vitamin D status among children under 7 years of age in some regions of China.
10.3760/cma.j.cn112140-20220126-00087
- VernacularTitle:中国部分地区7岁以下儿童维生素D营养状况分析
- Author:
Luan Luan LI
1
;
Xiao Nan LI
2
;
Fei Yong JIA
3
;
Mei Zhu CHI
4
;
Zhi Hong WEN
5
;
Fan YANG
6
;
Yu Ning LI
7
;
Li Jun HA
8
;
Ying YANG
9
;
Xiao Ling LONG
10
;
Shuan Feng FANG
11
;
Hui Feng ZHANG
12
;
Xiao Dan YU
1
Author Information
1. Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
2. Department of Child Health Care, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
3. Department of Developmental and Behavioral Pediatrics, the First Hospital of Jilin University, Changchun 130021, China.
4. Department of Child Health Care, the First Hospital of Wenzhou Medical University, Wenzhou 325000, China.
5. Department of Pediatrics, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
6. Department of Child Health Care, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
7. Department of Pediatrics, the First Hospital of Lanzhou University, Lanzhou 730013, China.
8. Department of Child Health Care, Yinchuan Maternity and Child Health Care Hospital, Yinchuan 750000, China.
9. Department of Child Health Care and Neurological Rehabilitation, Sports Center Branch of Dalian Municipal Women and Children's Medical Center (Group), Dalian 116033, China.
10. Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan 528405, China.
11. Department of Child Health Care, Children's Hospital of Zhengzhou University, Zhengzhou 450007, China.
12. Department of Pediatrics, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
- Publication Type:Journal Article
- MeSH:
Child;
China/epidemiology*;
Cross-Sectional Studies;
Humans;
Infant;
Vitamin D;
Vitamin D Deficiency/epidemiology*;
Vitamins
- From:
Chinese Journal of Pediatrics
2022;60(5):413-420
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore current vitamin D status and influential factors of vitamin D deficiency and insufficiency among children under 7 years of age in 11 provinces, autonomous regions or municipalities of China. Methods: According to the "province-city-hospital" sampling technical route, a total of 1 531 healthy children under 7 years of age were sampled from 11 provinces, autonomous regions or municipalities in China by the cluster random sampling method from November 2020 to November 2021. The demographic information, family conditions, behavior and living habits and feeding behaviors were collected using unified questionnaire. Serum 25-hydroxyvitamin D(25(OH)D) levels were measured by liquid chromatography-tandem mass spectrometry. Serum 25(OH)D<30 nmol/L was considered deficient and 30-50 nmol/L was considered insufficient. With 25(OH)D≤50 nmol/L as the dependent variable, multivariate Logistic regression was applied to analyze the association between vitamin D deficiency and insufficiency and potential influential factors. Results: The prevalence of vitamin D deficiency and insufficiency among children under 7 years of age in 11 provinces, autonomous regions or municipalities of China was 14.0% (215/1 531), 3.8% (25/664) and 21.9% (190/867) in 0-<3 and 3-<7 of age years, respectively. Compared to children aged 0-<3 years, children aged 3-<7 years had a 2.6-fold increased risk of vitamin D deficiency and insufficiency (OR=3.60, 95%CI 1.93-6.72, P<0.001). Frequent sunlight exposure (OR=0.46, 95%CI 0.29-0.73, P=0.001), vitamin D supplementation (sometimes, OR=0.33, 95%CI 0.21-0.51, P<0.001; daily, OR=0.20, 95%CI 0.11-0.36, P<0.001) and infant formula intake(4-7 times per weeks, OR=0.43, 95%CI 0.28-0.68, P<0.001) were protective factors for vitamin D deficiency and insufficiency. Conclusion: Vitamin D deficiency and insufficiency are common among children under 7 years of age in 11 provinces, autonomous regions or municipalities of China, which is affected by age, sunlight exposure, vitamin D supplementation and infant formula intake.
