Research progress of circumferential tracheal reconstruction via tissue-engineered trachea.
10.3760/cma.j.cn112139-20210206-00073
- Author:
Yong XU
1
;
Er Ji GAO
1
;
Liang DUAN
1
;
Ge Ning JIANG
1
Author Information
1. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
- Publication Type:Review
- MeSH:
Printing, Three-Dimensional;
Reconstructive Surgical Procedures;
Tissue Engineering;
Tissue Scaffolds;
Trachea/surgery*
- From:
Chinese Journal of Surgery
2022;60(1):104-109
- CountryChina
- Language:Chinese
-
Abstract:
Tissue engineering, as a new technology, provides a new avenue for the reconstruction of circumferential tracheal defects, which has always been a tremendous challenge for surgeons around the world. Recently, technologies such as decellularization, 3-dimensional printing, electrospinning and cell sheet have significantly enhanced the chondrification. Implantation of epithelial cells or transplantation of epithelial cell sheets also has accelerated the process of epithelialization. And pedicle muscle flap proved to be a reliable strategy for vascularization of tissue-engineered trachea. But it is still a huge challenge to achieve circumferential tracheal functional reconstruction. The key difficulty lies in how to simultaneously realize the functional regeneration of cartilage, blood vessels and epithelial tissues of tissue-engineered trachea. Therefore, how to integrate the above schemes and finally realize segmental tracheal reconstruction needs further research. This article reviews the research progress of repairing circumferential tracheal defects based on tissue engineering technology.
