Pituicytoma: a clinicopathological analysis of twenty-one cases.
10.3760/cma.j.cn112151-20210818-00579
- VernacularTitle:垂体细胞瘤21例临床病理学特征
- Author:
Xiao FENG
1
;
Wei BAO
1
;
Xuan WANG
1
;
Qiu RAO
1
;
Qun Li SHI
1
;
Zhen YUE
2
Author Information
1. Department of Pathology, Jinling Hospital, Nanjing 210002, China.
2. Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Child;
Child, Preschool;
Craniopharyngioma;
Female;
Glioma/pathology*;
Humans;
Immunohistochemistry;
Male;
Middle Aged;
Pituitary Neoplasms/pathology*;
Retrospective Studies;
Young Adult
- From:
Chinese Journal of Pathology
2022;51(4):314-318
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinicopathological features and treatment strategies of pituicytoma. Methods: Twenty-one cases of pituicytoma were collected at the First Affiliated Hospital of Nanjing Medical University and Jinling Hospital, Nanjing, China from 2009 to 2020. The clinical data of 21 pituicytoma patients was retrospectively analyzed, and the relevant literature was reviewed. Results: Twenty-one patients aged 4 to 68 years, including 8 males and 13 females. All patients underwent surgical treatment. Histologically, the tumor was consisted almost entirely of elongate, bipolar spindle cells arranged in a fascicular or storiform pattern. Mitotic figures were rare. Immunohistochemically, tumor cells were diffusely positive for S-100 protein (21/21), vimentin (15/15) and TTF1 (14/14), while they were weakly or focally positive for GFAP (13/16) and EMA (6/12). CKpan was negative in all cases and Ki-67 proliferation index was low (<5%). Among the 18 patients with follow-up, all survived and 2 relapsed after surgery. Conclusions: Pituicytoma is a rare low-grade glioma of the sellar area. It is easily confused with other sellar tumors. Preoperative diagnosis is difficult. It needs to be confirmed by histopathology and immunohistochemistry. Microsurgery is the main treatment method at present.
