Clinicopathological features of congenital hemangioma: a study of 40 cases.
10.3760/cma.j.cn112151-20211026-00776
- VernacularTitle:先天性血管瘤40例临床病理学特征研究
- Author:
Dong LIANG
1
;
Bo ZHOU
2
;
Na LI
1
;
Ling Fei KONG
3
;
Qiu Yu LIU
3
;
Yan Zhi DING
3
;
Kuai Lin NIU
4
;
Xiao Shuang ZHU
5
;
Hao Hui ZHU
6
Author Information
1. Department of Breast Surgery, Henan Provincial People's Hospital, Zhengzhou 450003, China.
2. Department of Pathology, Weishi People's Hospital, Kaifeng 475000, China.
3. Department of Pathology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
4. Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.
5. Department of Hemangioma, Henan Provincial People's Hospital, Zhengzhou 450003, China.
6. Department of Ultrasonography, Henan Provincial People's Hospital, Zhengzhou 450003, China.
- Publication Type:Journal Article
- MeSH:
Endothelial Cells/pathology*;
Female;
Hemangioendothelioma/pathology*;
Hemangioma/pathology*;
Humans;
Kasabach-Merritt Syndrome/pathology*;
Male;
Sarcoma, Kaposi/pathology*;
Skin Neoplasms/pathology*
- From:
Chinese Journal of Pathology
2022;51(3):202-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical and pathologic features, diagnosis and differential diagnosis of congenital hemangioma (CH). Methods: Forty cases of CH were diagnosed from January 2017 to December 2020 in Henan Provincial People's Hospital. The clinical and pathological and immunohistochemical data were analyzed, with review of literature. Results: There were 24 male and 16 female patients. The lesions were located in the head, neck (11 cases), limbs (14 cases), and trunk (15 cases). The clinical manifestations were congenital painless plaques or masses, the larger ones protruded on the skin surface, mostly dusky purple or bright red, with surrounding white halos. Under low magnification, the tumor was lobular and well demarcated, composed of neo-microvascular lumen of different sizes. The vascular endothelial cells were cuboidal or hobnail in appearance, forming stellar drainage vessels within the lobules. Extra-medullary hematopoiesis was seen in one case of rapidly involuting CH; there were different number of tortuous and dilated vascular lumen between the lobular structures, and some non-involuting CH cases were vascular malformations, which were devoid of lobulated structures. Immunohistochemistry showed that endothelial cells were strongly positive for CD31, CD34 and ERG, while D2-40 and GLUT-1 were negative. Conclusions: CH is a benign congenital vascular tumor with characteristic lobulated growth and abnormal blood vessels in the stroma. Pathological diagnosis often needs to be differentiated from infantile hemangioma, pyogenic granuloma, kaposiform hemangioendothelioma and vascular malformation.
