Analysis on epidemiological characteristics of dengue fever and E gene evolution of dengue virus in Guangzhou, 2020.
10.3760/cma.j.cn112338-20210930-00763
- VernacularTitle:2020年广州市登革热流行状况和病毒E基因进化特征分析
- Author:
Li Yun JIANG
1
;
Yuan LIU
1
;
Wen Zhe SU
1
;
Yi Min CAO
1
;
Wen Hui LIU
1
;
Biao DI
1
;
Zhi Cong YANG
1
Author Information
1. Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
- Publication Type:Journal Article
- MeSH:
China/epidemiology*;
Dengue/epidemiology*;
Dengue Virus/genetics*;
Disease Outbreaks;
Evolution, Molecular;
Genotype;
Humans;
Phylogeny
- From:
Chinese Journal of Epidemiology
2022;43(5):716-721
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the incidence of dengue fever and E gene evolution of dengue virus in Guangzhou in 2020 and understand the local epidemiological characteristics of dengue fever and spreading of dengue virus. Methods: The information of dengue fever cases in Guangzhou in 2020 was collected from Notifiable Infectious Disease System of Chinese Center for Disease Control and Prevention Information System. Serum samples from the cases were detected by real-time PCR. The E gene was sequenced and analyzed. Maximum likelihood phylogenetic trees were constructed using software MEGA 5.05. The statistical analysis was conducted using software SPSS 20.0. Results: A total of 33 dengue fever cases were reported in Guangzhou in 2020, including 31 (93.94%) imported cases and 2 (6.06%) local cases. Compared with the data during 2016 to 2019, the number of cases, overall incidence and local incidence all decreased with statistically significant differences (all P<0.05). The imported cases from Southeast Asia constituted 90.32% (28/31) of imported cases. The E gene sequences and the phylogenetic trees of imported and local cases demonstrated close relationship with the virus sequences from Southeast Asian, and they were less homologous with the sequences of dengue virus isolated in Guangzhou in previous years. Conclusions: The incidence of dengue in Guangzhou in 2020 was significantly affected by the imported cases, especially those from Southeast Asian countries. The study result demonstrated that dengue fever was not endemic in Guangzhou and it was caused by imported ones.
