Analysis on cancer incidence and mortality attributed to human papillomavirus infection in China, 2016.
10.3760/cma.j.cn112338-20211010-00777
- Author:
Mei Wen YUAN
1
;
Hong Hao WANG
1
;
Ru Fei DUAN
2
;
Kun Peng XU
3
;
Shang Ying HU
1
;
You Lin QIAO
4
;
Yong ZHANG
1
;
Fang Hui ZHAO
1
Author Information
1. Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
2. Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital/Yunnan Cancer Center, Kunming 650118, China.
3. Department of Quality Management, Dalian No.3 People's Hospital, Dalian 116044, China.
4. Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
China/epidemiology*;
Female;
Humans;
Incidence;
Laryngeal Neoplasms;
Male;
Middle Aged;
Mouth Neoplasms;
Oropharyngeal Neoplasms/epidemiology*;
Papillomavirus Infections/epidemiology*;
Penile Neoplasms/epidemiology*;
Registries;
Uterine Cervical Neoplasms/epidemiology*;
Vaginal Neoplasms;
Vulvar Neoplasms
- From:
Chinese Journal of Epidemiology
2022;43(5):702-708
- CountryChina
- Language:Chinese
-
Abstract:
Objective: We aim to evaluate the morbidity and mortality of cancer attributable to human papillomavirus (HPV) infection in China in 2016. Methods: Based on the cancer incidence and mortality rates, national population data, and population attributable fraction (PAF) in China, we calculated the number of incidence and death cases attributed to HPV infection in different areas, age groups, and gender in China in 2016. The standardized incidence and mortality rates for cancer attributed to HPV infection were calculated by using Segi's population. Results: In 2016, a total of 124 772 new cancer cases (6.32 per 100 000) were attributed to HPV infection in China, including 117 118 cases in women and 7 654 cases in men. Of these cancers, cervical cancer was the most common one, followed by anal cancer, oropharyngeal cancer, penile cancer, vaginal cancer, laryngeal cancer, oral cancer, and vulvar cancer. A total of 41 282 (2.03 per 100 000) deaths were attributed to HPV infection, of which 37 417 occurred in women and 3 865 in men. Most deaths were caused by cervical cancer, followed by anal cancer, oropharyngeal cancer, penile cancer, laryngeal cancer, vaginal cancer, oral cancer, and vulvar cancer. The incidence and mortality rates of cervical cancer increased rapidly with age, peaked in age group 50-54 years, then decreased obviously. The morbidity and mortality rates of non-cervical cancer increased with age. The cancer case and death numbers in rural areas (57 089 cases and 19 485 deaths) were lower than those in urban areas (67 683 cases and 21 797 deaths). However, the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of cervical cancer were higher in rural areas than in urban areas. There were no significant differences in ASIR and ASMR of non-cervical cancers between urban areas and rural areas. Conclusions: The incidence of cancers attributed to HPV infection in China was lower than the global average, but the number of incidences accounted largely, furthermore there is an increasing trend of morbidity and mortality. The preventions and controls of cervical cancer and male anal cancer are essential to contain the increases in cancer cases and deaths attributed to HPV infection.
