Dynamic changes and influencing factors of HIV-1 DNA load in HIV-1 infected individuals under antiretroviral therapy.
10.3760/cma.j.cn112338-20211129-00922
- Author:
Ji Bao WANG
1
;
Kai CHEN
2
;
Xiao Xia HE
3
;
Yu Rong GONG
1
;
Jin YANG
1
;
Xing DUAN
1
;
Yi Kui WANG
1
;
Yue Cheng YANG
1
;
Run Hua YE
1
;
Yan JIANG
4
;
Song DUAN
1
;
Wen Ge XING
4
Author Information
1. Dehong Dai and Jingpo Autonomous Prefectural Center for Disease Control and Prevention, Mangshi 678400, China.
2. Beijing Sanroad Biological Products Company Limited,Beijing 101407, China.
3. Beijing Engineering Technology Research Centre of Gene Sequencing and Gene Function Analysis, Beijing Engineering Research Center of Food Safety Analysis, Beijing Center for Physical & Chemical Analysis, Beijing 100089, China.
4. National HIV/AIDS Reference Laboratory, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
- Publication Type:Journal Article
- MeSH:
China/epidemiology*;
DNA/therapeutic use*;
HIV Infections/drug therapy*;
HIV Seropositivity;
HIV-1/genetics*;
Humans;
Male;
Viral Load
- From:
Chinese Journal of Epidemiology
2022;43(5):692-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the dynamic changes and influencing factors of HIV-1 DNA load in HIV-1 infected individuals under antiretroviral therapy (ART) in Dehong Dai and Jingpo autonomous prefecture, Yunnan province, and provide information support for the clinical use of HIV-1 DNA quantitative detection. Methods: The HIV infection cases in recent infection cohort from Dehong Center for Disease Control and Prevention during 2009-2018 were selected as study subjects. The dynamic curve of HIV-1 DNA load varrying with time was generated and logistic regression analysis was conducted to identify the risk factors for HIV-1 load in the recent follow up after ART and statistical analysis was performed by using SPSS 17.0. Results: Among the 113 HIV infection cases detected from the recent infection cohort, the recent HIV infection rate were 49.6%(56/113) males, sexual transmission cases and drug injection transmission cases accounted for 53.1% (60/113), 80.5% (91/113) and 19.5% (22/113), respectively. The dynamic changes curve showed that HIV-1 DNA load was relatively high (>800 copies /106 PBMCs) before ART, and droped rapidly (<400 copies /106 PBMCs) after ART for 1 year. However, HIV-1 DNA load decreased insignificantly from the second year of ART, and remained to be 269 copies/106 PBMCs after ART for 6 years. Univariable logistic regression analysis indicated that OR (95%CI) of CD8, CD4/CD8 and HIV-1 DNA load were 1.00 (1.00-1.00), 0.30 (0.09-1.05) and 1.01 (1.00-1.01), respectively. Multivariable logistic regression analysis showed that OR value of HIV-1 DNA load base was 1.00 (1.00-1.01). Conclusions: HIV-1 DNA load decreased significantly in the first year of ART, then remained stable for years. HIV-1 DNA load base was the key factor associated with the decrease of HIV-1 DNA load, the lower the HIV-1 DNA load base, the lower HIV-1 DNA load. Therefore, earlier ART can contribute to the decrease of HIV-1 DNA load.
