Gene-lifestyle interaction on coronary heart disease in adult twins of China.

Yu E XI; Wen Jing Gao; Jun Lyu; Can Qing YU; Sheng Feng Wang; Tao Huang; Dian Jian Yi Sun; Chun Xiao Liao; Yuan Jie Pang; Zeng Chang Pang; Min YU; Hua Wang; Xian Ping WU; Zhong Dong; Fan WU; Guo Hong Jiang; Xiao Jie Wang; Yu Liu; Jian Deng; Lin LU; Wei Hua Cao; Li Ming LI

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Gene-lifestyle interaction on coronary heart disease in adult twins of China.

Author: Yu E XI ¹ ; Wen Jing GAO ¹ ; Jun LYU ¹ ; Can Qing YU ¹ ; Sheng Feng WANG ¹ ; Tao HUANG ¹ ; Dian Jian Yi SUN ¹ ; Chun Xiao LIAO ¹ ; Yuan Jie PANG ¹ ; Zeng Chang PANG ² ; Min YU ³ ; Hua WANG ⁴ ; Xian Ping WU ⁵ ; Zhong DONG ⁶ ; Fan WU ⁷ ; Guo Hong JIANG ⁸ ; Xiao Jie WANG ⁹ ; Yu LIU ¹⁰ ; Jian DENG ¹¹ ; Lin LU ¹² ; Wei Hua CAO ¹ ; Li Ming LI ¹
Author Information

1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
3. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
4. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
5. Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China.
6. Beijing Center for Disease Prevention and Control, Beijing 100013, China.
7. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
8. Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
9. Qinghai Center for Diseases Prevention and Control, Xining 810007, China.
10. Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150090, China.
11. Handan Center for Disease Control and Prevention, Handan 056001, China.
12. Yunnan Center for Disease Control and Prevention, Kunming 650034, China.
Publication Type:Twin Study
MeSH: Adult; China/epidemiology*; Coronary Disease/genetics*; Diseases in Twins/genetics*; Humans; Life Style; Twins/genetics*; Twins, Dizygotic; Twins, Monozygotic
From: Chinese Journal of Epidemiology 2022;43(5):649-654
CountryChina
Language:Chinese
Abstract: Objective: To explore the gene-lifestyle interaction on coronary heart disease (CHD) in adult twins of China. Methods: Participants were selected from twin pairs registered in the Chinese National Twin Registry (CNTR). Univariate interaction model was used to estimate the interaction, via exploring the moderation effect of lifestyle on the genetic variance of CHD. Results: A total of 20 477 same-sex twin pairs aged ≥25 years were recruited, including 395 CHD cases, and 66 twin pairs both had CHD. After adjustment for age and sex, no moderation effects of lifestyles, including current smoking, current drinking, physical activity, intake of vegetable and fruit, on the genetic variance of CHD were found (P>0.05), suggesting no significant interactions. Conclusion: There was no evidence suggesting statistically significant gene-lifestyle interaction on CHD in adult twins of China.