A descriptive analysis on coronary heart disease in adult twins in China.
10.3760/cma.j.cn112338-20211229-01030
- Author:
Ji KE
1
;
Wen Jing GAO
1
;
Jun LYU
1
;
Can Qing YU
1
;
Sheng Feng WANG
1
;
Tao HUANG
1
;
Dian Jian Yi SUN
1
;
Chun Xiao LIAO
1
;
Yuan Jie PANG
1
;
Zeng Chang PANG
2
;
Min YU
3
;
Hua WANG
4
;
Xian Ping WU
5
;
Zhong DONG
6
;
Fan WU
7
;
Guo Hong JIANG
8
;
Xiao Jie WANG
9
;
Yu LIU
10
;
Jian DENG
11
;
Lin LU
12
;
Wei Hua CAO
1
;
Li Ming LI
1
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
3. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
4. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
5. Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China.
6. Beijing Center for Disease Prevention and Control, Beijing 100013, China.
7. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336,China.
8. Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
9. Qinghai Center for Diseases Prevention and Control, Xining 810007, China.
10. Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150090, China.
11. Handan Center for Disease Control and Prevention, Handan 056001, China.
12. Yunnan Center for Disease Control and Prevention, Kunming 650034, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
China/epidemiology*;
Coronary Disease/genetics*;
Diseases in Twins/genetics*;
Female;
Humans;
Male;
Twins, Dizygotic;
Twins, Monozygotic/genetics*
- From:
Chinese Journal of Epidemiology
2022;43(5):641-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe the distribution characteristics of coronary heart disease in adult twins recruited from Chinese Twin Registry (CNTR), and provide clues and evidence for the effect of genetic and environmental influences on coronary heart disease. Methods: By using the data of CNTR during 2010-2018, a total of 34 583 twin pairs aged ≥18 years who completed questionnaire survey and had related information were included in the current study to analyze the population and area distribution characteristics of coronary heart disease. Random effect models were used to compare the differences between groups. The concordane rate of coronary heart disease were calculated respectively in monozygotic (MZ) twin pairs and dizygotic (DZ) twin pairs to estimate the heritability. Results: The twin pairs included in this analysis were aged (34.2±12.4) years. The overall prevalence rate of coronary heart disease in twin pairs was 0.7%. Twin pairs who were women, older, obese and lived in northern China had higher prevalence of coronary heart disease (P<0.05). Intra-pair analysis in the same-sex twin pairs found that the concordane rate of coronary heart disease was higher in MZ twin pairs (25.3%) than in DZ twins (7.4%), and the difference was statistically significant (P<0.001). The overall heritability of coronary heart disease was 19.3% (95%CI: 11.8%-26.8%). Stratified by gender, age and area, the concordane rate was still higher in MZ twin pairs than in DZ pairs. Participants who were women, aged 18-30 years or ≥60 years and lived in northern China had a higher heritability of coronary heart disease. Conclusion: The distribution of coronary heart disease in twin pairs differed in populations and areas. The prevalence of coronary heart disease was affected by genetic factors, but the effect varied with age, gender and area.
