Association between genetic predisposition to childhood obesity and the risk of adult ischemic heart disease in China.
10.3760/cma.j.cn112338-20210413-00309
- Author:
Wen Xiu WANG
1
;
Ning Hao HUANG
1
;
Jun LYU
2
;
Can Qing YU
3
;
Yu GUO
4
;
Pei PEI
5
;
Huai Dong DU
6
;
Jun Shi CHEN
7
;
Zheng Ming CHEN
6
;
Tao HUANG
1
;
Li Ming LI
3
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Beijing 100191, China.
2. Department of Epidemiology and Biostatistics, School of Public Health, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.
3. Department of Epidemiology and Biostatistics, School of Public Health, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
4. Fuwai Hospital Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing 100037, China.
5. Chinese Academy of Medical Sciences, Beijing 100730, China.
6. Medical Research Council Population Health Research Unit/Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
7. China National Center for Food Safety Risk Assessment, Beijing 100022, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Body Mass Index;
Child;
China/epidemiology*;
Genetic Predisposition to Disease;
Humans;
Myocardial Ischemia/genetics*;
Pediatric Obesity/genetics*;
Prospective Studies;
Risk Factors
- From:
Chinese Journal of Epidemiology
2022;43(4):445-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine the associations of childhood obesity, assessed by genetic variations of childhood body mass index (BMI), with the risk of adult ischemic heart disease (IHD) and major coronary event (MCE). Methods: More than 69 000 participants from the China Kadoorie Biobank were genotyped. After excluding those with coronary heart disease, stroke, or cancer at baseline, a total of 64 454 participants were included in this study. Based on genome-wide significant single nucleotide polymorphisms (SNPs), childhood BMI genetic risk score were constructed for every participant and divided into quintiles, with the lowest quintile as the low genetic risk group and the highest quintile as the high genetic risk group. Cox proportional hazards regression models were used to estimate the association between genetic predisposition to childhood obesity and the risk of ischemic heart disease. Results: During a median of 10.7 years of follow-up, 7 073 incident cases of IHD and 1 845 cases of MCE were documented. After adjusting for sex, age, region, and the first ten genetic principal components, the HRs (95%CIs) for IHD and MCE in the high genetic risk group were 1.10 (1.02-1.18) and 1.10 (0.95-1.27), compared with the low genetic risk group. IHD risk increased by 4% (2%-6%) for each one standard deviation increase in genetic risk score (trend P=0.001). After further adjustment for baseline BMI, the differences between genetic risk groups were not statistically significant, but there was still a linear trend between genetic risk score and IHD risk (trend P=0.019). Conclusions: IHD risk increased with genetic predisposition to childhood obesity, suggesting that childhood obesity is an important risk factor for the development of IHD in China. As an easily identifiable feature, changes of childhood BMI should be monitored regularly to realize early intervention of IHD in adults.
