Association of blood lead and blood selenium with serum high-sensitivity C-reactive protein among Chinese adults aged 19 to 79 years.
10.3760/cma.j.cn112338-20210715-00555
- Author:
Sai Sai JI
1
;
Yue Bin LYU
1
;
Feng ZHAO
1
;
Ying Li QU
1
;
Zheng LI
1
;
Ya Wei LI
1
;
Shi Xun SONG
1
;
Wen Li ZHANG
1
;
Ying Chun LIU
1
;
Jia Yi CAI
1
;
Hao Can SONG
1
;
Dan Dan LI
1
;
Bing WU
2
;
Yang LIU
3
;
Xu Lin ZHENG
2
;
Jun Ming HU
1
;
Ying ZHU
1
;
Zhao Jin CAO
1
;
Xiao Ming SHI
2
Author Information
1. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
2. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
3. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China School of Public Health, Jilin University, Changchun 130012, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Asians;
Biomarkers;
C-Reactive Protein/analysis*;
China/epidemiology*;
Humans;
Male;
Middle Aged;
Risk Factors;
Selenium;
Young Adult
- From:Chinese Journal of Epidemiology
2022;43(2):195-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association of blood lead and blood selenium with serum high-sensitivity C-reactive protein (hs-CRP) among Chinese adults aged 19 to 79 years. Methods: The participants were enrolled from the first wave of China National Human Biomonitoring (CNHBM) conducted from 2017 to 2018. 10 153 participants aged 19 to 79 years were included in this study. Fasting blood samples were obtained from participants. Lead and selenium in whole blood and hs-CRP in serum were measured. Individuals with hs-CRP levels above 3.0 mg/L were defined as elevated hs-CRP. Generalized linear mixed models and restricted cubic spline models were used to analyze the association of blood lead and blood selenium with elevated hs-CRP. Logistic regression models were used to analyze the multiplicative scale and additive scale interaction between blood lead and blood selenium on elevated hs-CRP. Results: The age of participants was (48.91±15.38) years, of which 5 054 (61.47%) were male. 1 181 (11.29%) participants were defined as elevated hs-CRP. After multivariable adjustment, results from generalized linear models showed that compared with participants with the lowest quartile of blood lead, the OR (95%CI) of elevated hs-CRP for participants with the second, third, and highest quartiles were 1.14 (0.94-1.37), 1.25 (1.04-1.52) and 1.38 (1.13-1.68), respectively. When compared with participants with the lowest quartile of blood selenium, the OR (95%CI) of elevated hs-CRP for participants with the second, third and highest quartiles were 0.86 (0.72-1.04), 0.91 (0.76-1.11), and 0.75 (0.61-0.92), respectively. Results from the interaction analysis showed no significant interaction between lead and selenium on elevated hs-CRP. Conclusion: Blood concentration of lead was positively associated with elevated serum hs-CRP, and blood concentration of selenium was inversely related to elevated hs-CRP, while blood lead and selenium did not present interaction on elevated hs-CRP.
