Genetic variants, circulating levels of monocyte chemoattractant protein-1 with risk of breast cancer: a case-control study and Mendelian randomization analysis.
10.3760/cma.j.cn112150-20211107-01030
- VernacularTitle:趋化因子MCP1基因多态性、循环水平与乳腺癌的关联性：一项病例对照和孟德尔随机化研究
- Author:
Ke Ke MIAO
1
;
Jun LI
1
;
Li Na WU
1
;
Bin ZHANG
1
;
Meng Quan LI
1
Author Information
1. Department of Breast Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
- Publication Type:Journal Article
- MeSH:
Breast Neoplasms/genetics*;
Case-Control Studies;
Chemokine CCL2/genetics*;
Female;
Humans;
Mendelian Randomization Analysis;
Polymorphism, Single Nucleotide
- From:
Chinese Journal of Preventive Medicine
2022;56(5):590-594
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the association of genetic polymorphisms and circulating levels of chemokine monocyte chemoattractant protein-1 (MCP1) with risk of breast cancer. Methods: A total of 820 patients with pathologically confirmed breast cancer and 900 age-and area-of-residence-matched healthy controls who visited the hospital for routine health screening during the same period were included in this case-control study. Mendelian randomization analysis was performed using three widely followed functional single nucleotide polymorphisms (SNPs) of the MCP1 gene rs1024611, rs2857656 and rs4586 to construct instrumental variables . Results: MCP1 rs1024611 (OR=1.26, P=0.002), rs2857656 (OR=1.23, P=0.006) and rs4586 (OR=1.23, P=0.003) were significantly associated with increased risk of breast cancer. SNP rs1024611 (β=1.194, P<0.001), rs2857656 (β=1.221, P<0.001) and rs4586 (β=1.137, P<0.001) were positively correlated with higher circulating level of MCP1. The case-control study showed that an increase of 23.7 pg/ml of circulating levels of MCP1 was associated with a 0.25-fold increased risk of breast cancer. MR analysis confirmed that the genetic predicted circulating levels of MCP1 were associated with an increased risk of breast cancer, and the risk of breast cancer increased by 0.20 times with an increase of 23.7 pg/ml in MCP1. Conclusion: Genetic variants and circulating levels of MCP1 are significantly associated with the risk of breast cancer and can be used as a biomarker for early prediction of breast cancer.
