Early identification of a clustered epidemic of typhoid fever through pathogen molecular subtyping monitoring.
10.3760/cma.j.cn112150-20210430-00432
- VernacularTitle:病原菌分子分型监测在早期识别伤寒聚集性疫情中的应用
- Author:
Yan LIU
1
;
Muti MAHE
1
;
Fang LI
1
;
Xiayidan WUFUER
1
;
Hai Jian ZHOU
2
Author Information
1. Infectious Disease Prevention and Control Department, Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China.
2. Infectious Disease Prevention and Control Department, Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
- Publication Type:Journal Article
- MeSH:
Electrophoresis, Gel, Pulsed-Field;
Epidemics;
Humans;
Typhoid Fever/microbiology*
- From:
Chinese Journal of Preventive Medicine
2022;56(4):433-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To identify a suspected clustered Typhoid fever by whole genome sequencing(WGS) and pulsed field gel electrophoresis (PFGE) subtyping. Methods: The nature of the epidemic was determined by combination of subtyping results of isolates and epidemiological information. Results: Five S. typhimurium isolates showed identical PFGE patterns and almost the same whole genome sequence. Epidemiological survey showed that five cases had dined in the same restaurant on the same day. Conclusion: Combined with the longest incubation period of typhoid fever, molecular subtyping of pathogenic bacteria and the field epidemiological survey, it can be preliminarily determined that the five cases have common infection sources.
