The association between bisphenol A exposure and obesity/overweight in children and adolescents: dose-response Meta analysis.
10.3760/cma.j.cn112150-20210924-00922
- Author:
Fan WU
1
;
Man HU
1
;
Wei Dong QU
2
;
Ying ZHOU
1
Author Information
1. Department of Food and Nutrition and Chemistry in Public Health Science, School of Public Health, Fudan University, Shanghai 200032, China.
2. Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
- Publication Type:Meta-Analysis
- MeSH:
Adolescent;
Benzhydryl Compounds;
Child;
Humans;
Obesity/epidemiology*;
Overweight/epidemiology*;
Phenols
- From:
Chinese Journal of Preventive Medicine
2022;56(4):519-524
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between bisphenol A (BPA) exposure and obesity/overweight in children and adolescents through Dose-response Meta analysis. Methods: Articles published up to September 1st 2021 were systematically searched in PubMed, Web of science, Scopus, Embase, Cochrane library, CNKI, Wanfang databases and VIP Chinese Science and Technology Journal by using "bisphenol A" "BPA" "obesity" "weight" "fat""overweight" "body mass index" "BMI" "waist circumference" (both in English and in Chinese) as keywords. Use Stata 15.1 software to calculate the pooled OR (95%CI), perform heterogeneity test, subgroup analysis, sensitivity analysis, publication bias and the exposure-response relationship fitting. Results: A total of 9 English articles were included from 1 948 articles retrieved, including 8 articles from American and 1 article from China. 15 614 children/adolescents and 3 446 obese/overweight cases were further used for Meta-analysis of dose-response relationship. Meta-analysis results showed that there was heterogeneity among the highest dose groups in different studies(I2=52.1%, P=0.033). The random effect model-analysis found that compared with those in the lowest group, the OR(95%CI) for those in the highest group of urine BPA was 1.56(1.18-1.94)for the risk of obesity/overweight in children and adolescents, but there was no linear or nonlinear dose-response relationship. Sensitivity analyses showed that the results were robust, Egger's test(P=0.263) and Begg's test(P=0.348) showed that there was no publication bias. Conclusion: Bisphenol A exposure may increase the risk of obesity/overweight epidemics in children and adolescent.
