Epidemiological characteristics of Yersinia enterocolitica in patients with diarrhea from 2013 to 2019 in Pudong New Area, Shanghai.
10.3760/cma.j.cn112150-20210622-00603
- VernacularTitle:上海市浦东新区2013至2019年腹泻患者小肠结肠炎耶尔森菌流行特征分析
- Author:
Wen Qing WANG
1
;
Jing Hua SU
1
;
Yong Qi ZHANG
1
;
Bing ZHAO
1
;
Hong HUANG
1
;
Qi Qi CUI
1
;
Xue Bin XU
2
;
Li Peng HAO
1
Author Information
1. Department of Microbiology, Pudong New Area Center for Disease Control and Prevention,Shanghai 200136, China Fudan University Pudong Institute of Preventive Medicine,Shanghai 200136,China.
2. Institute for Microbiology,Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
- Publication Type:Journal Article
- MeSH:
Ampicillin;
Anti-Bacterial Agents/pharmacology*;
Child;
China/epidemiology*;
Diarrhea/epidemiology*;
Humans;
Yersinia enterocolitica
- From:
Chinese Journal of Preventive Medicine
2022;56(4):479-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the epidemiological characteristics of Yersinia enterocolitica in patients with diarrhea in Pudong New Area, Shanghai. Methods: Active surveillance of diarrhea was conducted in 14 sentinel hospitals (three tertiary-level hospitals, nine secondary-level hospitals, and two primary-level hospitals) from January 2013 to December 2019 in Pudong New Area of Shanghai, China base on their location, catchment area, and patient volume. Cold enrichment method was used to isolate Y. enterocolitica and further detection of bioserotype, virulence genes and antimicrobial susceptibility of the isolates were conducted. The difference of rates was determined using chi-square test or Fisher's exact test. Results: A total of 12 941 diarrhea cases were included, and 0.7% (88/12 941) cases were confirmed with Yersinia enterocolitica infection. 67.0% (59/88) cases were single infection, 33.0% (29/88) cases were mixed infections. Detection rates of Y. enterocolitica increased annually (0.3%-1.2%) and were highest in children<5 years of age (1.1%, 37/3 218) and in spring (1.1%, 32/2 998) (χ2 were 18.64 and 9.76, respectively, P<0.05). 58.0% (51/88) cases had watery diarrhea, 15.9% (14/88) had fever and 14.8% (13/88) had vomiting. The predominant bioserotypes were 3/O:3 (53.4%, 47/88), followed by 1A/O:8 (15.9%, 14/88) and 1A/O:5(6.8%, 6/88), respectively. Bioserotype 3/O:3 counted for the highest proportions (89.2%, 33/37) in children <5 years of age. All the strains of bioserotype 3/O:3 harbored ail, ystA, yadA and virF genes, which encoded pathogenic Y. enterocolitica. 11/14 strain of 1A/O:8 and 4/6 strains of 1A/O:5 harbored ystB gene. Most strains were resistant to ampicillin (80.7%,71/88) and amoxicillin/clavulanic acid (71.6%,63/88), and 63.8% (56/88) strains were multidrug resistance (MDR). The difference of antimicrobial resistance rates between 3/O:3 and non 3/O:3 was statistically significant in ampicillin, cefoxitin, nalidixic acid, tetracycline and ampicillin/sulbactam (χ2 was 14.68, 43.80, 41.86, 30.54 and 5.07, respectively, P<0.05). Conclusion: The detection rate of Yersinia enterocolitica was higher in children than in adults in Pudong New Area , Shanghai. The predominant bioserotype was pathogenic 3/O:3 with multidrug resistance.
