Infection and distribution characteristics of HPV of middle-aged and elderly women from a certain hospital in Guangxi Zhuang Autonomous Region from 2018 to 2020.
10.3760/cma.j.cn112150-20210929-00931
- Author:
Xiao Ning WEI
1
;
Xin Yu XU
2
;
Shao Wei WANG
1
Author Information
1. Department of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China Graduate School of Peking Union Medical College, Beijing 100730, China.
2. Graduate School of Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Aged;
China/epidemiology*;
Female;
Hospitals;
Human papillomavirus 16;
Humans;
Male;
Middle Aged;
Papillomaviridae/genetics*;
Papillomavirus Infections/genetics*;
Uterine Cervical Neoplasms
- From:
Chinese Journal of Preventive Medicine
2022;56(4):468-473
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To analyze the type and distribution characteristics of human papillomavirus (HPV) infection along with cervical cytology in middle-aged and elderly women in Guangxi and to provide a basis for the prevention and treatment of cervical cancer in elderly women. Methods: 21 subtypes of HPV and cervical cytology of women over 45-year-old visiting the First Affiliated Hospital of Guangxi Medical University from January 2019 to December 2020 were collected. They were divided into two groups by age, 45-64 years group and over 65 years group. The HPV, HR-HPV, and multiple HPV infection prevalence were analyzed, as well as HPV genotypes, the age distribution of HPV infection rate, and cervical cytology. Results: A total of 6 657 eligible women were included. 6 238 women were in the 45-64 years group, with a HPV prevalence about 20.86% (1 301), while 419 women were in the over 65 years group, with a HPV prevalence about 32.94% (138). The age-associated HPV and HR-HPV prevalence increased with the age, peaking at the age group of 70-74 years (P<0.001). The most prevalent genotype was HPV52, and the infection rate was 5.3% (353), followed by HPV16 and HPV 58, about 4.63% (308) and 3.08% (205) respectively. The majority cytology of HPV-positive middle-aged and elderly women was normal. 8.70% (88) of them were ASC-US, 6.52% (66) for HSIL, 4.55% (46) for LSIL, and 2.96% (30) for ASC-H, and 0.10% (1) for SCC. Compared to middle-aged women, elderly women had a lower negative cytology rate, 69.79% (67) vs. 77.95% (714), but a higher HSIL rate, 13.54% (13) vs. 5.79% (53) (P<0.05). Conclusions: HPV and HR-HPV prevalence of elderly women in a medical center of Guangxi are higher than those of middle-aged women. The most prevalent genotype is HPV16 in elderly women, followed by HPV52 and HPV58.
