Combined application of field epidemiology and laboratory etiology analysis in the investigation of a foodborne disease outbreak in Xinjiang uygur Autonomous Region, 2016.
10.3760/cma.j.cn112150-20210427-00421
- Author:
Xin MA
1
;
Fang LI
2
;
Wan Li LIU
3
;
Xi Jiang WANG
4
;
Xue Bing WANG
5
;
Hai Jian ZHOU
6
;
Guo Qing SHI
7
Author Information
1. Institute of Infectious Disease Control and Prevention, Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China.
2. Health Monitoring and Testing Center, Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China.
3. Laboratory Management Office, Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China.
4. Tuberculosis and leprosy prevention and treatment center, Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China.
5. State Key Laboratory of Infectious Disease Prevention and Control/National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
6. Institute of Infectious Disease Control and Prevention, Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China State Key Laboratory of Infectious Disease Prevention and Control/National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
7. Chinese Field Epidemiology Training Program Chinese Center for Disease Control and Prevention, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Disease Outbreaks;
Electrophoresis, Gel, Pulsed-Field;
Foodborne Diseases/epidemiology*;
Humans;
Staphylococcus aureus/genetics*
- From:
Chinese Journal of Preventive Medicine
2022;56(4):448-452
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To analyze the causes of a foodborne outbreak in rural areas of Xinjiang between April 2 and April 5 in 2016. Methods: Cases and the relevant background information were obtained by consulting outpatient records of local health centers and regional people's hospitals and interviewing doctors and residents. All samples were collected by the laboratory test through epidemiological and food hygiene investigations. The χ2 test (Fisher's exact probability method) was used to compare differences in incidence rates. Molecular typing, virulence genes and single nucleotide polymorphisms (SNPS) were analyzed by using Pulsed Field Gel Electrophoresis (PFGE) and Whole Genome Sequencing (WGS). Results: A total of 142 cases were found in this study, with incidence rate at 5.7‰ (142/24 979). Among all cases, the main symptoms were nausea (94%), vomiting (92%) and abdominal pain (67%), and the incubation period was about 2 h (1-7.5 h). There were 16 Staphylococcus aureus isolates identified and all of them could produce A+C+E mixed enterotoxin. PFGE showed 100% homology. WGS further revealed that there were 9 and 1 strains contained by Sequence Type 1 (ST1) and ST5405, respectively. All ST1 strains were in the same clade on the genome tree. Among these, 7 strains shared close proximity (74 SNPs) and 2 strains shared close relationships as well (127 SNPs). The S. aureus isolates that caused the outbreak were introduced by a mutant isolate from the milk supply station. Conclusions: This foodborne outbreak was mainly caused by Staphylococcus aureus contamination.
