Associations between plasma n-3 polyunsaturated fatty acids and gestational diabetes mellitus in the second trimester.
10.3760/cma.j.cn112150-20210428-00422
- Author:
Yan LIU
1
;
Yi Xiang YE
2
;
Yi WANG
2
;
Fan WANG
2
;
Yi Chao HUANG
3
;
Da CHEN
4
;
Xiong Fei PAN
5
;
An PAN
2
Author Information
1. Chengdu Shuangliu District Maternal and Child Health Hospital, Chengdu 610000, China.
2. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
3. Department of Health Toxicology, School of Public Health, Anhui Medical University, Hefei 230032, China.
4. College of Environment, Jinan University, Guangzhou 510632, China.
5. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Child;
Diabetes, Gestational;
Fatty Acids, Unsaturated;
Female;
Glucose Tolerance Test;
Humans;
Pregnancy;
Pregnancy Trimester, Second
- From:
Chinese Journal of Preventive Medicine
2022;56(3):312-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine the associations between plasma n-3 polyunsaturated fatty acids (PUFAs) in the second trimester and gestational diabetes mellitus (GDM) among Chinese pregnant women. Methods: Based on data from the Tongji-Shuangliu Birth Cohort enrolled from 2017 to 2019 in the Shuangliu Maternal and Child Health Hospital, it conducted a case-control study among 269 GDM cases who were diagnosed by 75 g oral glucose tolerance test, and 538 non-GDM controls matched at a 1∶2 ratio on maternal age and gestational weeks. The age range of the 807 women was 18-40 years. Fasting plasma n-3 PUFAs were determined by gas chromatography-mass spectrometry in the second trimester (24-28 weeks). Participants were categorized into quartiles (Q1-Q4) of plasma n-3 PUFAs based on distributions in the control group. Conditional logistic regression models were applied to estimate the associations between plasma n-3 PUFAs and GDM. Results: The median (interquartile) relative concentrations of plasma n-3 PUFA C22∶5n-3 was significantly lower in women with GDM 0.87 (0.72, 1.07) compared with women without GDM 0.94 (0.75, 1.19)(P=0.001). Plasma n-3 PUFA C22∶5n-3 was inversely associated with GDM, with an OR (95%CI) of 0.75 (0.62-0.90) for each SD increase of relative concentration. Compared with the Q1 group, the OR values and 95%CIs of Q2, Q3, and Q4 groups were 0.97 (0.62-1.51), 0.72 (0.45-1.15), and 0.54 (0.32-0.90), respectively (Ptrend<0.05). However, there were no significant associations of C18∶3n-3, C20∶5n-3, C22∶6n-3, and total n-3 PUFAs with GDM. Conclusion: Plasma n-3 PUFA C22∶5n-3 was inversely associated with GDM during the second trimester.
