Prenatal pyrethroid pesticides exposure and neurodevelopment of 2-year-old children: a birth cohort study.
10.3760/cma.j.cn112150-20210927-00926
- VernacularTitle:农村妇女孕全程拟除虫菊酯类农药暴露对2岁儿童神经发育影响的队列研究
- Author:
Zhi Ye QI
1
;
Xiao Xiao SONG
2
;
Xia XIAO
2
;
Qing Hua XU
3
;
Jie WU
4
;
Guang Ping GUO
5
;
Shu Qi CHEN
2
;
Ying CHEN
2
;
Ling Ling XU
2
;
Yan LI
2
Author Information
1. Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
2. School of Public Health, Kunming Medical University, Kunming 650500, China.
3. Yunnan Institute of Pediatric Research, Kunming Children's Hospital, Kunming 650228, China.
4. Department of Pediatrics, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
5. Yunnan Maternal and Child Health Care Hospital, Kunming 650021, China.
- Publication Type:Journal Article
- MeSH:
Birth Cohort;
Child Development;
Child, Preschool;
Cohort Studies;
Female;
Humans;
Infant;
Maternal Exposure/adverse effects*;
Pesticides/adverse effects*;
Pregnancy;
Pregnancy Trimester, Third;
Prenatal Exposure Delayed Effects/chemically induced*;
Pyrethrins/metabolism*
- From:
Chinese Journal of Preventive Medicine
2022;56(3):270-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the influence and critical windows of prenatal exposure to pyrethroid pesticides (PYRs) on neurodevelopment of 2-year-old children. Methods: The subjects of this study were derived from the Xuanwei Birth Cohort. A total of 482 pregnant women who participated in the rural district of Xuanwei birth cohort from January 2016 to December 2018 were included. Maternal urinary concentrations of PYRs metabolites during 8-12 gestational weeks, 20-23 gestational weeks and 32-35 gestational weeks were measured with ultra high performance liquid chromatography system coupled with a tandem mass spectrometry detector. Child neurodevelopment was evaluated with the Bayley Scales of Infant and Toddler Development-Third Edition at 2 years of age. Multivariate linear regression models and binary logistic regression models were used to assess the association between PYRs exposure during pregnancy and children's neurodevelopment. Results: A total of 360 mother-child pairs had complete data on maternal urinary PYRs metabolites detection and children's neurodevelopment assessment. The detection rate of any one PYRs metabolites during the first, second and third trimester were 93.6% (337/360), 90.8% (327/360) and 94.2% (339/360), respectively. The neurodevelopmental scores of Cognitive, Language, Motor, Social-Emotional, and Adaptive Behavior of 2-year-old children were (102.3±18.9), (100.2±16.3), (102.0±20.3), (107.8±23.3) and (85.8±18.6) points, respectively. After controlling for confounding factors, 4-fluoro-3-phenoxybenzoic acid (4F3PBA, one of PYRs metabolites) exposure in the first trimester reduced Motor (β=-5.02, 95%CI: -9.08, -0.97) and Adaptive Behavior (β=-4.12, 95%CI:-7.92, -0.32) scores of 2-year-old children, and increased risk of developmental delay of adaptive behavior (OR=2.07, 95%CI:1.13-3.82). Conclusion: PYRs exposure during the first trimester of pregnancy may affect neurodevelopment of 2-year-old children, and the first trimester may be the critical window.
