Evaluation of immune persistence of vaccine.
10.3760/cma.j.cn112150-20210216-00150
- VernacularTitle:疫苗免疫持久性评价
- Author:
Ying CHEN
1
;
Hong Lu ZHOU
1
;
Yu Liang ZHAO
2
;
Xuan Yi WANG
3
Author Information
1. The Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
2. Vaccine Clinical Research institute of Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021,China.
3. The Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China MoE & NHC Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 200032, China Children's Hospital of Fudan University, Shanghai 201102, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Immunity;
Meta-Analysis as Topic;
Vaccines/immunology*
- From:
Chinese Journal of Preventive Medicine
2022;56(2):212-217
- CountryChina
- Language:Chinese
-
Abstract:
The evaluation methods of immune persistence include direct evaluation, indirect evaluation, model prediction, and meta-analysis and so on. Direct evaluation is the gold standard for evaluating the immune persistence of vaccines by quantifying the protective effect of vaccines on the onset and (or) infection of preventable diseases. Indirect evaluation of immune persistence by immunological surrogate indicators is more widely used in practice. In addition, mathematical models and meta-analysis can also be used to evaluate the immune persistence of vaccines. It is of great significance to select the appropriate evaluation method to analyze the immune persistence of the vaccine according to the specific situation.
