Current status and progress of precision nutritional weight management guided by single nucleotide polymorphism.
10.3760/cma.j.cn112150-20210727-00717
- VernacularTitle:基于单核苷酸多态性指导的精准营养减重现状及进展
- Author:
Mo Xi CHEN
1
;
Wei CHEN
1
Author Information
1. Department of Clinical Nutrition, Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Gene-Environment Interaction;
Genome-Wide Association Study;
Humans;
Life Style;
Obesity/prevention & control*;
Polymorphism, Single Nucleotide
- From:
Chinese Journal of Preventive Medicine
2022;56(2):132-138
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of obesity in our country is increasing year by year. Diet and lifestyle interventions are the most commonly used weight loss measures, but their intervention effects are affected by individual genetics, environment and other factors. Genome-wide association analysis has found many SNPs related to weight loss, and explored the interaction between these loci and diet, intestinal flora and other environmental factors. This article summarizes the study of single nucleotide polymorphisms, the analysis of gene-environment interactions related to diet interventions for weight loss, and the multi-loci analysis and prediction models such as genetic risk scores and machine learning modeling in weight loss, which provides reference for the further application and development of the precise nutrition in medical weight loss.
