Advanced progress of ex vivo biosensor assay in toxicological evaluation.
10.3760/cma.j.cn112150-20210507-00444
- Author:
Wen Ting CHENG
1
;
Yu Xin ZHENG
1
;
Jing Long TANG
1
Author Information
1. Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266021, China.
- Publication Type:Journal Article
- MeSH:
Biosensing Techniques;
Environmental Pollutants/toxicity*;
Humans;
Risk Assessment;
Toxicity Tests
- From:
Chinese Journal of Preventive Medicine
2022;56(1):25-28
- CountryChina
- Language:Chinese
-
Abstract:
The ex vivo biosensor assay is developed to assess the health effects and toxicological mechanism of environmental pollutants with internal environment homeostasis changes by integrating the in vivo exposure evaluation, in vitro outcomes analysis, and systematic environment component screening. This toxicology testing model combines the real-world exposure of people in the field and the study of molecular mechanism exploration in lab experiments to overcome the shortcomings of a single toxicology method. It provides a new technique and perspective for toxicity testing and risk assessment in mesoscale between macroscopic population study and microscopic mechanism exploration.
