Advances on molecular typing methods and evolution of human parainfluenza virus.
10.3760/cma.j.cn112150-20211022-00983
- Author:
Jie JIANG
1
;
Wen Bo XU
1
;
Yan ZHANG
1
;
Zhen ZHU
1
;
Nai Ying MAO
1
Author Information
1. WHO WPRO Regional Reference Laboratory of Measles and Rubella/NHC Key Laboratory of Medical Virology and Viral Diseases/National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing 102206, China.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
Molecular Typing;
Parainfluenza Virus 1, Human/genetics*;
Parainfluenza Virus 2, Human/genetics*;
Parainfluenza Virus 3, Human/genetics*;
Paramyxoviridae Infections/epidemiology*;
Respiratory Tract Infections/epidemiology*
- From:
Chinese Journal of Preventive Medicine
2022;56(2):203-211
- CountryChina
- Language:Chinese
-
Abstract:
Human parainfluenza viruses (HPIVs) is one of the main causes of acute respiratory tract infections in children. HPIVs have been grouped into four serotypes (HPIV1~HPIV4) according to serological and genetic variation. Different serotypes of HPIVs have diverse clinical disease spectrum, epidemic characteristics and disease burden. Based on the nucleotide variation in structural protein genes, HPIVs can be further divided into distinct genotypes and subtypes with diverse temporal and spatial distribution features. The standard molecular typing methods are helpful to clarify the gene evolution and transmission patterns of HPIVs in the process of population transmission. However, the development of molecular epidemiology of HPIVs has been hindered by the lack of a standardized molecular typing method worldwide. Therefore, this study reviewed the viral characteristics, genome structure, existing genotyping methods and evolution of HPIVs, and screened the reference strains for molecular typing, so as to improve the understanding of gene characteristics and molecular typing of HPIVs, and provide an important scientific basis for the monitoring and research of molecular epidemiology of HPIVs in China.
