The expression of cortactin in colorectal cancer and its relationship with clinicopathological and prognostic parameters.
10.3760/cma.j.cn112152-20210226-00172
- VernacularTitle:结直肠癌中皮动蛋白的表达与病理特征及预后的关系
- Author:
Chuan Duo ZHAO
1
;
Si Cheng ZHOU
1
;
Hao SU
1
;
Jian Wei LIANG
1
;
Zhi Xiang ZHOU
1
Author Information
1. Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China.
- Publication Type:Journal Article
- Keywords:
Adjuvant chemoradiotherapy;
Colorectal neoplasms;
Cortactin;
Prognosis;
Tissue microarray
- MeSH:
Biomarkers, Tumor/metabolism*;
Carcinoembryonic Antigen/metabolism*;
Colorectal Neoplasms/pathology*;
Cortactin/metabolism*;
Humans;
Prognosis;
Retrospective Studies
- From:
Chinese Journal of Oncology
2022;44(3):268-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of cortactin in colorectal cancer and its correlation with clinicopathological parameters and prognosis. Methods: The expressions of cortactin in normal colorectal mucosal tissue and colorectal cancer tissue in paraffin-embedded tissue microarray from 319 patients who were diagnosed as colorectal cancer and treated in Cancer Hospital of Chinese Academy of Medical Sciences from 2006 to 2009 was detected by immunohistochemistry. Kaplan-Meier method and Log rank test were used for survival analysis, and Cox proportional risk regression model was used for multivariate analysis. Results: The positive expression rates of cortactin in colorectal cancer tissue and normal colorectal mucosal tissue were 61.1% (195/319) and 5.6% (18/319, P<0.001), respectively. T-stage, N-stage, American Joint Committee on Cancer (AJCC) stage, degree of tumor differentiation, neural invasion and preoperative carcinoembryonic antigen (CEA) levels were associated with the expression of cortactin (P<0.05). The positive expression of cortactin was associated with poorer disease-free survival (P=0.036) and overall survival (P=0.043), and the effect was more significant in patients with stage Ⅱ to Ⅲ. For patients with stage Ⅱ-Ⅲ colorectal cancer, postoperative adjuvant therapy was associated with disease-free survival (P=0.007) and overall survival (P=0.015). The vascular tumor embolus, pathological type, preoperative CEA level and cortactin expression were independent influencing factors for disease-free survival (P<0.05). The age, AJCC stage, preoperative CEA level and cortactin expression were independent influencing factors for overall survival (P<0.05). Preoperative CEA level and cortactin expression were independent influencing factors for disease-free survival and overall survival (P<0.05). Conclusion: Cortactin is expressed in colorectal cancer and in stage Ⅱ-Ⅲ patients, it is a potential predictor of colorectal cancer prognosis.
