Clinical features of Chinese patients with Takotsubo syndrome.
10.3760/cma.j.cn112148-20220307-00155
- Author:
Zheng Feng LU
1
;
Tao Juan CHONG
2
;
Jian CHEN
3
;
Wei WU
4
;
Kan LIU
5
Author Information
1. Department of Emergency, Kiang Wu Hospital, Macau Special Administrative Region People's Republic of China 999078,China.
2. Department of Cardiology, Kiang Wu Hospital, Macau Special Administrative Region People's Republic of China 999078,China.
3. Department of Cardiology, Fifth Affiliated Hospital, Sun Yat-sen University,Zhuhai 519000, China.
4. Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
5. Division of Cardiology and Heart and Vascular Center of University of Iowa, Iowa 52242, USA.
- Publication Type:Review
- MeSH:
Adult;
Aged;
Echocardiography;
Electrocardiography;
Female;
Humans;
Middle Aged;
Stroke Volume/physiology*;
Takotsubo Cardiomyopathy/diagnosis*;
Ventricular Function, Left/physiology*
- From:
Chinese Journal of Cardiology
2022;50(4):375-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the characteristics, diagnosis and treatment status of Takotsubo syndrome (TTS) of Chinese patients. Methods: Complete literature review was performed to summarize Chinese TTS cases between 2007 and 2018. Results: A total of 131 literatures were included including 160 TTS patients (age (58.3±14.7) years). There were 137 female patients (85.6%) in this cohort, the age was (59.6±14.0) years. There were 124 cases (77.5%) of stress-evoking factors, of which 83 cases (66.9%) were self-stress factors. There were 97 cases (60.6%) complained of chest pain and 15 cases (9.4%) with syncope. Forty-eight cases (30.0%) presented with cardiogenic shock. CK-MB and cTnT/I increased in 109 cases (80.1%). There were 124 cases (77.5%) presented with ST segment elevation on electrocardiogram, which were common in lead V2-V5. Echocardiography results were available in 128 cases (80.0%), reduced left ventricular ejection fraction (<50%) was reported in 78 cases (73.6%). Coronary angiography was performed in 133 patients (83.1%), of which 126 patients (94.7%) had normal coronary arteries or single non-significant stenosis. One hundred and thirty-eight patients (87.3%) were apical type. The misdiagnosis rate on admission was 96.9% (155/160), of which 141 cases (88.1%) were misdiagnosed as acute myocardial infarction. Nitroglycerin was used in 36 patients (30.3%). Angiotensin converting enzyme inhibitor or angiotensin Ⅱ receptor antagonist were used in 38 patients (31.9%). β blockers were used in 46 patients (38.7 %). Dopamine was used in 22 cases (18.5%) and norepinephrine was used in 12 cases (10.1%). Intra-aortic balloon counter pulsation was used in 5 cases (3.1%). Cardiopulmonary resuscitation was performed in 9 cases (5.6%). Cardiac function recovery time was 7 (6, 15) days. The average InterTAK diagnosis score was (51.5±18.1) points, and value was>70 points in 2 cases (1.3%). There were 92 patients in the high-risk group, and there were 3 recurrent TTS cases. Five patients died. Conclusions: TTS incidence tends to be young and dominates in female in China. The misdiagnosis rate is extremely high on admission. Most patients are treated with medication.
