Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases
https://doi.org/10.5704/MOJ.2203.022
- Author:
Saw KY
1
;
Anz AW
2
;
Jee CSY
3
;
Ramlan A
3
;
Dawam A
3
;
Low SF
4
Author Information
1. Department of Orthopaedic Surgery, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia
2. Department of Orthopaedics, Andrews Institute for Orthopaedics and Sports Medicine, Gulf Breeze, United States
3. Stem Cells R and D, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia
4. Department of Radiology, Kuala Lumpur Sports Medicine Centre, Kuala Lumpur, Malaysia
- Publication Type:Journal Article
- Keywords:
end-stage ankle arthritis, massive chondral defects, chondrogenesis, peripheral blood stem cells, marrow stimulation
- From:Malaysian Orthopaedic Journal
2022;16(No.1):134-137
- CountryMalaysia
- Language:English
-
Abstract:
End-stage ankle arthritis represents an “unmet medical
need”, awaiting an appropriate time for joint arthroplasty or
arthrodesis. We report three cases of end-stage ankle arthritis
treated along the principles developed for chondrogenesis of
the knee joint with autologous peripheral blood stem cells,
resulting in reversal of the ankle arthritis. The improvement
in clinical outcome measure scores (Ankle Osteoarthritis
Scale total score) with a minimum two-year follow-up were
comparable to total ankle replacement (TAR), arthroscopic
ankle arthrodesis (AAA) and open ankle arthrodesis (OAA).
- Full text:16.2022my1239.pdf
