Relationship between Cytochrome P450 1A2 Gene Polymorphism and Susceptibility to Chronic Obstructive Pulmonary Disease

VernacularTitle:沈阳汉族人群细胞色素P450 酶1A2基因多态性与慢性阻塞性肺疾病易感性的关联
Author: Long ZHAO ; Ying LI ; Da CHEN ; Tao MA ; Linhui XU ; Shuyue XIA
Publication Type:Journal Article
Keywords: chronic obstructive pulmonary disease, cytochrome P450 1A2, gene polymorphism, susceptibility
From: Chinese Journal of Rehabilitation Theory and Practice 2014;(9):873-876
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between cytochrome P450 1A2 (CYP1A2) gene polymorphism and susceptibility to chronic obstructive pulmonary disease (COPD). Methods CYP1A2 gene polymorphisms in 100 COPD cases and 100 healthy controls were tested with polymerase chain reaction- restriction fragment length polymorphism (PCR- RELP). Results Genotype frequencies of 4 SNPs in both the COPD and control groups were in accordance with Hardy-Weinberg equilibrium (P>0.05). There was significant difference between the COPD and control groups in genotype and allele frequencies of 1D and 1F (P<0.05), but not of 1C and 1E (P>0.05). Conclusion CYP1A2*1D and CYP1A2*1F polymorphisms may play an important role in the development of COPD.