Effects of Instant Hyperbaric Oxygen Therapy on Brain Edema and Expression of Aquaporin-4 after Cerebral Ischemia in Rats
10.3969/j.issn.1006-9771.2014.09.008
- VernacularTitle:即时高压氧治疗对大鼠脑缺血后脑水肿及水通道蛋白4 表达的影响
- Author:
Fangyuan CHEN
;
Min YU
;
Lixin ZHANG
;
Zhiqiang ZHANG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia, hyperbaric oxygen, neurological score, brain edema, aquaporin-4, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2014;(9):823-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of instant hyperbaric oxygen (HBO) therapy on brain edema and aquaporin-4 (AQP4) expression after cerebral ischemia in rats. Methods 18 healthy adult male Sprague-Dawley rats were randomly divided into sham group (n=6),control group (n=6) and HBO group (n=6). Middle cerebral artery occlusion model was established with modified Longa method in the control group and HBO group. HBO was administered after cerebral ischemia immediately in HBO group for 60 min. They were observed with the neurological function score, brain tissue water content and AQP4 experssion 6 h after operation. Results Compared with the control group, the neurological score in HBO group improved significantly (P<0.05), while the brain tissue water content and brain AQP4 expression decreased (P<0.05). Conclusion HBO may improve the neurological function and brain edema after cerebral ischemia, which may relate with inhibiting the expression of AQP4.
