Low-dose Perioperative Dexamethasone Improves 24-hour Post-Operative Pain after Anterior Cruciate Ligament Reconstruction
https://doi.org/10.5704/MOJ.2203.011
- Author:
Khatri K
1
;
Sidhu G
2
;
Jindal S
2
;
Bansal D
3
;
Goyal D
4
Author Information
1. Department of Orthopaedics, All India Institute of Medical Sciences, Bathinda, India
2. Department of Anaesthesia, Guru Gobind Singh Medical College and Hospital, Faridkot, India
3. Department of Orthopaedics, AIMC Bassi Hospital, Ludhiana, India
4. Department of Orthopaedics, Dr. Goyal Bone and Joint Clinic, New Delhi, India
- Publication Type:Journal Article
- Keywords:
knee, anterior cruciate ligament reconstruction, postoperative pain, dexamethasone
- From:Malaysian Orthopaedic Journal
2022;16(No.1):76-83
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Post-operative pain following anterior
cruciate ligament reconstruction remains an important
challenge. Steroids are used in various surgical procedures to
decrease post-operative nausea, vomiting and pain.
However, only a few studies have reported the effect of
systemic administration of steroids in controlling postoperative pain after anterior cruciate ligament surgery.
Materials and methods: We have conducted a prospective
randomised trial with 109 patients divided into two groups to
determine if administration of dexamethasone in the
perioperative period improves pain in the post-operative
period. The patients were divided into two groups: D,
treatment (dexamethasone) and P, control placebo (saline).
Patients in the D treatment group were given the first dose of
10mg of intravenous dexamethasone intravenously intraoperatively and the second dose on transferring of the patient
to the inpatient department. The patients in the placebo P
group, were administered normal saline in the perioperative
period in a similar manner.
Result: Post-operative pain was significantly less in the
dexamethasone group at rest and on walking (p<0.001) for
the first 24 hours after surgical procedure. Subsequently, the
VAS pain scores were almost similar in both groups at 48
and 72 hours. The administration of dexamethasone resulted
in less requirement of antiemetic and rescue analgesia
medication There was no difference in range of motion and
wound complications rate during the follow-up period at six
months. No adverse side effect, like osteonecrosis of the hip,
was detected.
Conclusion: The pain following anterior cruciate ligament
reconstruction is severe during the first 24 hours and
perioperative administration of dexamethasone can decrease
the post-operative pain substantially.
- Full text:16.2022my1228.pdf
