Polymorphisms of Surfactant Protein Genes and Chronic Obstructive Pulmonary Disease Risk: A Meta- analysis
10.3969/j.issn.1006-9771.2014.07.020
- VernacularTitle:肺表面活性物质蛋白基因多态性与慢性阻塞性肺疾病易感性关联的Meta分析
- Author:
Lin ZHANG
;
Yun ZHANG
;
Zhifeng ZHANG
;
Wenhan ZHANG
;
Chunxiao FANG
;
Liyan YU
- Publication Type:Journal Article
- Keywords:
surfactant protein, polymorphism, chronic obstructive pulmonary disease, Meta-analysis
- From:
Chinese Journal of Rehabilitation Theory and Practice
2014;(7):683-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between polymorphisms in surfactant protein (SP) genes and susceptibility to chronic obstructive pulmonary disease (COPD). Methods An extensive literature search for relevant studies was conducted in databases of Wanfang Data, VIP, Google Scholar, PubMed, CNKI, CBM, EMBASE and Web of Science and so on from inception to Sep., 2013. A meta-analysis was then performed using Stata 12.0 software. Results 7 case-control studies were included with a total of 1,279 COPD cases and 1,482 healthy controls. This meta-analysis revealed that polymorphisms of the SP-A gene might be associated with an increased risk of COPD (allele model: OR=1.53, 95%CI: 1.14~2.05, P=0.005; dominant model: OR=1.65, 95%CI: 1.02~2.69, P=0.043; recessive model: OR=1.66,95%CI: 1.17~2.35, P=0.005: homozygous model: OR=2.06, 95%CI: 1.24~3.41, P=0.005; eterozygous model: OR =1.59, 95%CI: 1.13~2.22, P=0.007; respectively). However, there was no evidence for any association between polymorphisms of the SP-B and SP-D genes and COPD risk (all P>0.05). Further subgroup analysis by ethnicity suggested that SP-A genetic polymorphisms were associated with an increased risk of COPD among Asians, but not among Caucasians. Conclusion SP-A genetic polymorphisms may contribute to increasing susceptibility to COPD, especially among Asians.
