Diagnosis and treatment strategy of intestinal flora imbalance after liver transplantation
10.3969/j.issn.1674-7445.2022.04.009
- VernacularTitle:肝移植术后肠道菌群失调的诊疗策略
- Author:
Zhiye BAO
1
;
Hao LIU
Author Information
1. Department of Organ Transplantation and Hepatobiliary Surgery, the First Hospital of China Medical University, Key Laboratory of Organ Transplantation of Liaoning Province, Shenyang 110001, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
Intestinal flora imbalance;
Probiotics;
Fecal microbiota transplantation;
Short chain fatty acid;
Shannon diversity index;
Total parenteral nutrition (TPN);
Selective decontamination of the digestive tract (SDD)
- From:
Organ Transplantation
2022;13(4):469-
- CountryChina
- Language:Chinese
-
Abstract:
Multiple short-term and long-term complications might occur after liver transplantation. In the early stage after liver transplantation, the incidence of multidrug-resistant bacteria is likely to cause different types of infection, one of which is intestinal flora imbalance. In the recent decade, a series of studies have demonstrated that intestinal flora plays an important role in maintaining intestinal homeostasis. Intestinal flora may interact with other organs via multiple patterns. Among which, gut-liver axis is one of the most critical channels for regulating microenvironment of the host. Changes in the quantity and composition of intestinal flora could lead to intestinal flora imbalance. In both local and systemic systems, extensive interaction exists between intestinal flora and immune system. In this article, the risk factors of intestinal flora imbalance after liver transplantation, influence of intestinal flora imbalance on liver transplant recipients and relevant treatment strategies were reviewed.
