Diagnostic criteria and research progress on Banff classification of allograft pathology in composite tissue allotransplantation
10.3969/j.issn.1674-7445.2022.04.003
- VernacularTitle:同种异体复合组织移植Banff移植病理学诊断标准及进展
- Author:
Yan XIONG
1
;
Qifa YE
;
Fanhua KONG
;
Hui GUO
Author Information
1. Institute of Hepatobiliary Diseases, Zhongnan Hospital of Wuhan University, National Quality Management and Control Center for Human Donated Organ Procurement, Transplantation Medical Center of Wuhan University, Key Laboratory of Transplantation Technology of Hubei Province, Wuhan 430071, China
- Publication Type:Research Article
- Keywords:
Composite tissue allotransplantation (CTA);
Vascularized composite allotransplantation (VCA);
Biopsy;
Antibody-mediated rejection (AMR);
T cell-mediated rejection (TCMR);
C4d staining;
Graft-versus-host reaction (GVHR);
Donor specific antibody (DSA)
- From:
Organ Transplantation
2022;13(4):425-
- CountryChina
- Language:Chinese
-
Abstract:
Composite tissue allotransplantation (CTA) is a novel transplantation discipline to treat functional tissue or limb defects. Since a majority of CTA grafts were vascularized grafts, it is also known as vascularized composite allotransplantation (VCA). The grafts of CTA/VCA consist of two or more types of allogeneic skin, subcutaneous tissue, bone, muscle, nerve and vessel, etc. Most of CTA/VCA grafts contain skin tissues, which possess the highest antigenicity. Acute rejection after transplantation is the primary obstacle leading to CTA/VCA graft failure and primary graft dysfunction. Hence, histopathological characteristics of skin rejection in CTA/VCA grafts have become the primary hotspot. In this article, pathological features of CTA/VCA rejection, Banff classification in 2007 and related research progress were reviewed, aiming to provide reference for the diagnosis and treatment of rejection and other complications of CTA/VCA.
