Reflection on 10 problems of clinical xenotransplantation
10.3969/j.issn.1674-7445.2022.04.001
- VernacularTitle:临床异种器官移植十大问题的思考
- Author:
Kefeng DOU
1
;
Xuan ZHANG
Author Information
1. Department of Hepatobiliary Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China
- Publication Type:Research Article
- Keywords:
Xenotransplantation;
Genome editing;
Rejection;
Inflammation;
Coagulation disorder;
Physiological compatibility;
Interspecific infection;
Immunosuppressive regimen
- From:
Organ Transplantation
2022;13(4):411-
- CountryChina
- Language:Chinese
-
Abstract:
The shortage of donors restricts the development of organ transplantation. Xenotransplantation might act as an effective approach to resolve this problem. With the advancement of genome editing technologies as well as research and development of novel immunosuppressant, lots of breakthroughs have been achieved in the field of xenotransplantation. Nevertheless, a majority of researches are still in the preclinical stage. Recently, the success of the world's first genetically engineered pig-to-human heart transplantation has greatly inspired researchers. However, clinical xenotransplantation still faces an array of problems, including counteracting rejection, controlling inflammation, regulating coagulation disorder, improving physiological compatibility of xenografts, paying attention to the risk of interspecific infection, optimizing immunosuppressive regimen, screening donor genome editing types, selecting suitable recipients, modifying xenotransplantation guidelines, and awareness of public recognition, etc. In this article, these 10 problems were summarized, aiming to provide reference for promoting the clinical application of xenotransplantation.
