Progress of the possible mechanism of leucine-rich repeat kinase 2 affecting thyroid cancer via regulating autophagy
10.3760/cma.j.cn115355-20210515-00215
- VernacularTitle:富含亮氨酸重复序列激酶2调控自噬影响甲状腺癌可能机制的研究进展
- Author:
Lixing WANG
1
;
Yu LIU
;
Duohan ZHANG
;
Yinlong ZHAO
;
Lili ZHONG
Author Information
1. 吉林大学第二医院核医学科，长春 130041
- Keywords:
Thyroid neoplasms;
Autophagy;
Leucine-rich repeat kinase 2
- From:
Cancer Research and Clinic
2022;34(5):387-389
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid cancer is the most common malignant tumor of the endocrine system, and the incidence is increasing year by year, which seriously threatens people's health. Autophagy is a programmed mode of death that can be used as a potential target for anti-tumor therapy and plays an important regulatory role. Leucine-rich repeat kinase 2 (LRRK2) is a protein kinase encoded by PARK8 gene. The recent studies have confirmed that autophagy is closely related to thyroid cancer. This paper analyzes the possible regulatory mechanism of LRRK2 affecting thyroid cancer through autophagy, providing new ideas for basic research and clinical diagnosis and treatment of thyroid cancer.
