Effects of marital status on survival of early stage breast cancer patients: a real-world study
10.3760/cma.j.cn115355-20211205-00560
- VernacularTitle:婚姻状况对早期乳腺癌患者生存影响的真实世界研究
- Author:
Hefei LIU
1
;
Tengfei LONG
;
Lu LIU
;
Qi ZHANG
;
Hongyan ZHANG
Author Information
1. 中国科学技术大学附属第一医院离子医学中心（合肥离子医学中心）放疗科，合肥 230088
- Keywords:
Breast neoplasms;
Marital status;
Prognosis
- From:
Cancer Research and Clinic
2022;34(3):198-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the real-world marital status is a factor affecting the survival of patients with early stage breast cancer.Methods:According to the data of 62 845 patients with early stage (T 1-2N 0M 0) breast cancer who received treatment from January 2012 to December 2015 in the Surveillance, Epidemiology and End Results (SEER) database, univariate survival analysis for 7 factors including age, race, surgery, T stage, tumor differentiation, molecular type and marital status was performed by Kaplan-Meier method. The 5-year cancer specific survival (5-CSS) rate was calculated. Multivariate Cox proportional hazards model was used to analyze the death risk of patients with different marital status (married, unmarried and bad marriage). Results:Univariate analysis showed that 7 factors were correlated with the survival of patients with early stage breast cancer (all P < 0.001). Multivariate analysis showed that marital status was an independent factor affecting the survival of patients, and the death risk of unmarried patients and patients with bad marriage was 2.014 times (95% CI 1.714-2.367, P < 0.001) and 2.559 times (95% CI 2.254-2.905, P < 0.001) higher than that of married patients, respectively. In tumor differentiation, molecular type, T stage and race subgroups, univariate analysis showed that the rates of 5-CSS in married patients were higher than those in unmarried patients and patients with bad marriage (all P < 0.001); multivariate analysis showed that the risk of death in patients with bad marriage (except undifferentiated type) was higher than that in married patients (all P < 0.001), and the risk of death in unmarried patients (except undifferentiation, Luminal B type, black and other races) was also higher than that in married patients (all P < 0.01). Conclusions:Marital status is one of the factors influencing the survival of patients with early stage breast cancer.
