The role progress of RNA binding protein human antigen R in lung cancer
10.3760/cma.j.cn115355-20210710-00303
- VernacularTitle:RNA结合蛋白人类抗原R在肺癌中的作用研究进展
- Author:
Guipeng CHENG
1
;
Hui XIAO
Author Information
1. 上海市第一人民医院呼吸与危重症医学科，上海 200080
- Keywords:
Lung neoplasms;
Human antigen R;
Molecular mechanism;
Treatment;
Prognosis
- From:
Cancer Research and Clinic
2022;34(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the main cause of cancer-related deaths, and its morbidity and mortality is the highest, which seriously affects patients' survival time and quality of life. To develop new targets of tumor cells and expand the beneficiary population of lung cancer patients have become a hot and difficult research topic in recent years. RNA binding protein human antigen R (HuR) plays an important role in the development and progression of lung cancer. It can affect the transcription, translation and synthesis of multiple genes, proteins and molecules of lung cancer cells by binding to specific mRNA in lung cancer cells, and promote proliferation, differentiation and apoptosis of lung cancer cells. HuR is of great significance in molecular diagnosis, treatment and prognosis of lung cancer. This article will review the biological characteristics of HuR and research progress of its interaction with HuR-related regulatory factors in lung cancer based on relevant domestic and foreign literatures.
