A Case of Scleroderma-like Cutaneous Lesions Induced by Docetaxel in a Patient with Breast Cancer.
10.4078/jrd.2013.20.5.323
- Author:
Jun Su BYUN
1
;
Seung Hwa KANG
;
Min Jae LEE
;
So Yeon KIM
;
Hyung Gyu CHOI
;
Hyo Rak LEE
Author Information
1. Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea. cisplatin@kcch.re.kr
- Publication Type:Case Report
- Keywords:
Scleroderma-like cutaneous lesion;
Docetaxel;
Skin lesion
- MeSH:
Alopecia;
Biopsy;
Breast Neoplasms*;
Breast*;
Creatinine;
Electrolytes;
Endoscopy, Digestive System;
Female;
Humans;
Liver Function Tests;
Lower Extremity;
Middle Aged;
Neutropenia;
Rheumatoid Factor;
Sclerosis;
Skin;
Taxoids;
Thorax;
Thyroid Function Tests;
Ultrasonography, Doppler;
Urea
- From:Journal of Rheumatic Diseases
2013;20(5):323-327
- CountryRepublic of Korea
- Language:English
-
Abstract:
Docetaxel, an anti-microtubule agent, has been reported to show cytotoxic effects in solid tumors. Its toxicities also include neutropenia, alopecia, skin reaction, and fluid retention. In this study, we report on a case of a 57-year-old Korean female who presented with rapidly progressive scleroderma-like cutaneous changes in the upper and lower extremities after administration of docetaxel. Results of the following tests were normal or negative: full blood count, serum urea, creatinine, electrolytes, liver function test, thyroid function test, rheumatoid factor, anti-nuclear antibody, and anti-topoisomerase antibody. No structural abnormalities were noted on esophagogastroduodenoscopy, chest computed tomography, and Doppler ultrasonography. A biopsy of skin from the left calf showed dermal sclerosis. There was no other explanation for the lesion, except a scleroderma-like cutaneous change induced by docetaxel in this Korean female undergoing treatment for breast cancer.
