A case of epithelioid hemangioendothelioma diagnosed by bone marrow cell morphology
10.3760/cma.j.cn114452-20211023-00566
- VernacularTitle:骨髓细胞形态学检查诊断上皮样血管内皮细胞瘤1例
- Author:
Liqing LUO
1
;
Shouyan CAO
;
Wenhui CHU
;
Zhenyi PENG
Author Information
1. 滨州医学院附属医院血液科，滨州 256603
- Keywords:
Epithelioid hemangioendothelioma;
Bone marrow cell morphology;
Diagnosis
- From:
Chinese Journal of Laboratory Medicine
2022;45(5):549-552
- CountryChina
- Language:Chinese
-
Abstract:
Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor. Its malignancy is between benign hemangioma and highly malignant angiosarcoma. It originates from vascular endothelial cells or pre-endothelial cells. It is characterized by the proliferation of vascular endothelial cells with a skin-like or histiocyte-like appearance. The incidence of EHE is less than 1% in all vascular tumors, and it can occur in multiple parts of the body, most often in the liver, followed by simultaneous involvement of the liver and lung, the lung alone, and the bone alone. At present, there is no report of epithelioid hemangioendothelioma diagnosed by bone marrow cell morphological examination in China. In this case, abnormal cells were found through bone marrow cell morphological examination, which guided the direction of further diagnosis and treatment. And finally the patient was diagnosed as epithelioid hemangioendothelioma. The bone marrow cell morphological examination can provided an important basis for clinical diagnosis and treatment. Epithelioid hemangioendothelioma needs to be differentiated from a variety of benign and malignant angiogenic tumors, especially other types of epithelioid angiogenic tumors. At present, it has been found that the disease has characters of cytogenetic and molecular biological abnormalities. Combined with histopathological morphology and immunohistochemical examination, we can make the diagnosis and differential diagnosis.
