Study on the correlation between male serum calcitonin gene-related peptide and the embryo culture outcome after in vitro fertilization
10.3760/cma.j.cn114452-20211115-00714
- VernacularTitle:男性血清降钙素基因相关肽与体外受精胚胎培养结局的相关性研究
- Author:
Jiajing CHEN
1
;
Jianfeng CHEN
;
Jiali CHEN
;
Shuxian CHEN
;
Zhiren LIU
;
Qinyuan YOU
;
Cuilan ZHANG
;
Qicai LIU
Author Information
1. 福建医科大学附属第一医院生殖医学中心，福州 350005
- Keywords:
Calcitonin gene-related peptide;
Infertility, male;
In Vitro Fertilization;
Normal fertilization rate
- From:
Chinese Journal of Laboratory Medicine
2022;45(5):439-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum calcitonin gene-related peptide (CGRP) and the culture outcome of in vitro fertilization embryo in male patients with infertility.Methods:In this study, the randomized samples from 25 male patients who received in vitro fertilization-embryo transfer (IVF-ET) in the 1st Affiliated Hospital of Fujian Medical University from June 2019 to October 2019 were analyzed by multiple linear stepwise regression, with some important clinical outcomes, such as the logarithmic conversion index of serum CGRP, fertilization method, masturbation difficulty, age, infertility duration, and prolactin, as independent variables, while total fertilization rate, normal fertilization rate, high quality embryo rate at day 3, blastocyst formation rate as dependent variables.Results:The Pearson correlation analysis showed that the D3 high-quality embryo rate was related to the normal sperm morphology rate in the primary infertility group ( r=0.537, P=0.048), the blastocyst formation rate was correlated with sperm density ( r=0.760, P=0.002), the CGRP logarithm was correlated with the total fertilization rate ( r=0.693, P=0.006). The logarithmic conversion index of serum CGRP was related to the total fertilization rate and normal fertilization rate in the secondary infertility group ( r=0.614, P=0.042 and r=0.611, P=0.046). In the secondary infertility group, there was a linear relationship between normal fertilization rate and total sperm count, serum CGRP log conversion, and sperm normal morphology rate, with standardized regression coefficients of 0.2, -0.729, and 6.8, respectively. Conclusion:Serum CGRP level, together with total sperm count and normal sperm morphology rate may affects normal fertilization rate in male patients with infertility.
