A potential therapeutic target: platelet glycosylation
10.3760/cma.j.cn114452-20220107-00008
- VernacularTitle:一种潜在的治疗靶点：血小板糖基化
- Author:
Chenxue QU
1
;
Liping LI
Author Information
1. 北京大学第一医院检验科，北京100034
- Keywords:
Blood platelets;
Glycoproteins;
Glycosylation
- From:
Chinese Journal of Laboratory Medicine
2022;45(4):323-326
- CountryChina
- Language:Chinese
-
Abstract:
Platelet surface is rich in glycocalyx. It has been found that platelet glycosylation plays an important role in the physiological hemostasis mechanism, regulating the interaction between platelets and receptor proteins, and dynamically reshaping the surface glycosylation through its own glucose metabolism system. Platelet glycosylation also participates in platelet aging and clearance, and regulates platelet counts. Meanwhile, abnormal platelet glycosylation is closely related to primary immune thrombocytopenia, coronary heart disease and other related diseases, being a potential therapeutic target.
