Glycomic technology and its application in disease marker mining
10.3760/cma.j.cn114452-20220208-00056
- VernacularTitle:糖组学技术及其在疾病标志物挖掘中的应用
- Author:
Shifang REN
1
;
Jianxin GU
Author Information
1. 复旦大学基础医学院生物化学与分子生物学系 国家卫生健康委员会糖复合物重点实验室，上海 200032
- Keywords:
Glycomics;
Mass Spectrometry;
Glycan markers
- From:
Chinese Journal of Laboratory Medicine
2022;45(4):318-322
- CountryChina
- Language:Chinese
-
Abstract:
Changes in protein glycosylation modification have been found to be closely related to cancer and other diseases. Profiling glycosylation change has become an effective way to explore the diagnosis and treatment markers. The accuracy of quantitative technology is the key to reveal the mystery of glycosylation, and the screening and validation of glycosylation disease markers is dependant on the study of large clinical samples. Therefore, glycomic technology are expected to be simple, rapid, high-throughput, accurate and practical. In this paper, the characteristics of some commonly used glycomic analysis techniques and their applications in glycan markers are briefly discussed, and the characteristics, progress and applications of high-throughput precision glycome quantitative methods based on MALDI MS are emphasized.
