Research progress of nanopore sequencing in the clinic
10.3760/cma.j.cn114452-20210618-00383
- VernacularTitle:基于纳米孔测序技术的临床检测研究进展
- Author:
Ye LIU
1
;
Xiaomao XU
Author Information
1. 北京医院呼吸与危重症医学科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730
- Keywords:
Molecular diagnostic techniques;
Nanopore sequencing;
Nucleic acid testing
- From:
Chinese Journal of Laboratory Medicine
2022;45(3):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Because of the low throughput of current first-generation sequencing and the shortread length of second-generation sequencing, a new technology that overcomes the above shortcomings has emerged. The third-generation sequencing based on nanopore does not rely on the chain reaction of DNA polymerases and distinguishes bases by identifying electrical signals. It has broad application prospects and also faces more challenges. At present, it has many applications in detection of infectious pathogens, infectious disease prevention and control, genetic variation, and tumor diagnosis.
