Potential diagnostic and therapeutic targets and anti-tumor mechanisms of Neddylation pathway in digestive system tumors
10.3760/cma.j.cn114452-20211108-00692
- VernacularTitle:消化系统肿瘤中Neddylation修饰通路的潜在诊疗靶点与机制
- Author:
Liangshan LI
1
;
Shiwen WANG
;
Yanmei ZHANG
;
Hu ZHAO
Author Information
1. 复旦大学附属华东医院检验科，上海 200040
- Keywords:
Alimentary system;
Digestive system tumors;
Neddylation;
MLN4924;
Molecular diagnostic and therapeutic targets
- From:
Chinese Journal of Laboratory Medicine
2022;45(3):220-225
- CountryChina
- Language:Chinese
-
Abstract:
Neddylation,a novel post-translational modification of proteins, is overactivated in digestive system tumors and can be used as a potential anti-tumor molecular target. Targeting Neddylation pathway plays an anti-tumor role by inducing cell cycle arrest, apoptosis, senescence and autophagy of digestive system tumor cells, as well as enhancing the sensitivity of digestive system tumor cells to the radiotherapy and chemotherapy. Targeting Neddylation pathway and its inhibnitor MLN4924 can act as poential targets against digestive system tumors.
