Value of the biomarkers derived from cerebrospinal fluid in the diagnosis of Alzheimer disease
10.3760/cma.j.cn114452-20210901-00553
- VernacularTitle:脑脊液生物标志物在阿尔茨海默病诊断中的价值
- Author:
Xiaomin ZHANG
1
;
Yuting CUI
;
Jingjing ZHANG
;
Yifei WANG
;
Peichang WANG
Author Information
1. 首都医科大学宣武医院检验科，北京 100053
- Keywords:
Cerebrospinal fluid;
Biomarker;
Alzheimer disease
- From:
Chinese Journal of Laboratory Medicine
2022;45(1):8-13
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer disease (AD) is a neurodegenerative disease in the elderly. Early intervention is the only reliable means to delay the progress of the disease. Referring to the diagnostic criteria of AD, this paper summarizes and analyzes the representative literatures of various AD biomarkers derived from cerebrospinal fluid in recent years, and reviews the efficacy of various cerebrospinal fluid biomarkers in the diagnosis and differential diagnosis of AD. Results show that CSF Aβ42, Aβ42/Aβ40, T-tau, p-tau, Aβ42/p-tau, growth-associated protein 43, synaptosomal-associated protein 25, neurogranin and visinin-like protein-1 are of great value in the diagnosis and differential diagnosis of AD. The above CSF biomarkers can be used in the diagnosis and differential diagnosis of AD. The laboratory should select appropriate AD CSF biomarkers according to its own conditions in daily laboratory works.
