Pay attention to the diagnosis and treatment of fundus complications related to tumor immunotherapy

VernacularTitle:重视肿瘤免疫治疗相关眼底并发症的诊断与治疗
Author: Ling CHEN ¹ ; Yixian MA ; Wei WANG ; Gezhi XU
Author Information

1. 复旦大学附属眼耳鼻喉科医院眼科,　上海　200031
Keywords: Neoplasms; Immunotherapy; Uveitis; Scleritis; Editorial
From: Chinese Journal of Ocular Fundus Diseases 2022;38(5):341-345
CountryChina
Language:Chinese
Abstract: Cancer immunotherapy refers to the therapeutic effect of controlling or eliminating tumor cells by interfering with the immune system to restore the anti-tumor immune response. Immune checkpoint inhibitor therapy that blocks programmed death -1/programmed cell death ligand-1/cytotoxic T lymphocyte-associated antigen 4 is one of the most commonly used tumor immunotherapies, with good efficacy and wide application. These drugs cause immune-related ocular complications such as uveitis, autoimmune retinopathy, and scleritis, which represent a new etiology of ocular inflammation. The ophthalmologist's grasp of the clinical characteristics of these diseases is helpful for timely diagnosis. At the same time, the ophthalmologist will work closely with the oncologist to make a comprehensive judgment based on the patient's primary tumor, survival prognosis, severity of adverse reactions related to ocular immunotherapy, and visual prognosis, and develop suitable therapeutic strategie, thereby saving the patients' vision and improving the quality of life.