Research progress of circular RNA in ocular fundus diseases
10.3760/cma.j.cn511434-20210218-00082
- VernacularTitle:环状RNA在眼底疾病中的研究进展
- Author:
Ying WANG
1
;
Xue CHEN
;
Qinghuai LIU
Author Information
1. 南京医科大学第一附属医院眼科，南京 210029
- Keywords:
RNA;
Retinal diseases;
Diabetic retinopathy;
Eye neoplasms;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(4):334-339
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) is a new group of endogenous non-coding RNAs produced by back-splicing, which has multiple molecular functions such as acting as microRNA sponges, regulators of transcription and splicing, adaptors for protein-protein interaction. Recent studies have shown that circRNA play an essential role in development and progression of retinal microvascular dysfunction, diabetic retinopathy, age-related macular degeneration, proliferative vitreoretinopathy, eye diseases caused by hyperhomocysteine and ocular malignancy. In pathological conditions, the differential expression of circRNA alters the transcription and translation of corresponding genes, thus changing the activity and function of cells. CircRNA may become a new marker and prognostic indicator of fundus diseases, and its targeted intervention may also become a potential treatment for fundus diseases.
