Research progress of single-cell transcriptome sequencing in uveal melanoma
10.3760/cma.j.cn511434-20220130-00063
- VernacularTitle:单细胞转录组测序在葡萄膜黑色素瘤中应用的研究进展
- Author:
Hanqing ZHAO
1
;
Jingting LUO
;
Yang LI
;
Wenbin WEI
Author Information
1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼内肿瘤诊治研究北京市重点实验室 北京市眼科学与视觉科学重点实验室 医学人工智能研究与验证工信部重点实验室, 北京 100730
- Keywords:
Uveal Neoplasms;
Melanoma;
Tumor Microenvironment;
Transcriptome;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(3):248-252
- CountryChina
- Language:Chinese
-
Abstract:
Uveal melanoma (UM) is an aggressive and lethal tumor in the eye. The complexity and heterogeneity of UM and its microenvironment leads to a lack of strategies for early prevention and treatment of metastases. Single-cell sequencing technologies provide critical insights into deciphering the complexity of intratumor heterogeneity and the microenvironment by enabling genomic, transcriptomic, and epigenetic analysis at the single-cell level. With the help of bioinformatics analysis combined with artificial intelligence algorithms, molecular indicator systems related to prognosis as well as therapeutic targets can be found, which can provide a basis for guiding the selection of clinical treatment plans. However, the single-cell sequencing technology also has certain limitations, such as high sample requirements, expensive and time-consuming sequencing. It is believed that with the improvement of science and technology and the update of analytical methods, these shortcomings can be gradually solved, and this rare tumor will eventually be overcome in the future, and the goal of long-term survival of UM patients will be achieved.
